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Previous Figure Next Figure. Email or Customer ID. Forgot password? Old Password. New Password. Password Changed Successfully Your password has been changed. Returning user. Request Username Can't sign in? Forgot your username? Enter your email address below and we will send you your username. The extracts significantly reduced fasting glucose levels in diabetic rats and also reduced the lipid profile parameters in diabetic rats.

In conclusion, our histopathological investigation along with the biochemical evaluations suggests the strong antidiabetic potential of Artemisia amygdalina. Further mechanistic studies are required to suggest the appropriate mechanism for the antidiabetic effect of the plant. They are also highly thankful to Mr. Showkat Ahmad Teli, Mr. Shafiq Ahmad Khan, Mr.

Anti‑allergic effect of Artemisia extract in rats

Bashir Ahmad Bhat, and Mr. Ashiq Ahmad Bhat for their valuable contribution to plant collection, allocation of animals, and maintenance of animal house. The authors declare that they have no conflict of interests regarding the publication of this paper. Europe PMC requires Javascript to function effectively.

Recent Activity. The snippet could not be located in the article text. This may be because the snippet appears in a figure legend, contains special characters or spans different sections of the article. Biomed Res Int. Published online May PMID: Khalid Ghazanfar , 1 , 2 Bashir A. Tantry 3. Bashir A. Mudasir A. Ganai: moc. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC.

Abstract Artemisia species have been extensively used for the management of diabetes in folklore medicine. Introduction Diabetes mellitus is a metabolic disorder characterized by a loss of glucose homeostasis, with disturbances of carbohydrate, fat, and protein metabolism resulting from defects in insulin secretion, insulin action, or both [ 1 ]. Materials and Methodology 2. Plant Material and Extraction The plant material was collected from the local areas of Kashmir and was identified by the Centre of Taxonomy, University of Kashmir.

Experimental Animals Albino Wistar rats weighing — g of either sex were selected for the study. Experimental Design All the animals were randomly divided into several groups with five animals in each, serving as normal nondiabetic , diabetic control, diabetic treated with different extracts, and diabetic reference control, that is, glibenclamide. Induction of Diabetes Diabetes was induced in albino Wistar rats by a single intraperitoneal i. Assessment of Effects of Extracts on Biochemical Parameters Oral administration with plant extracts was started 72 h after streptozotocin injection in diabetic rats while normal group and diabetic control group were administered only with vehicle.

Effect of Extracts on Body Weight, Feed Consumption, and Water Consumption The effect of the extracts hydroethanolic and methanolic on parameters like body weight, feed consumption, and water consumption were determined and recorded during the study period. Histopathological Studies On the 14th day, all the animals were sacrificed and pancreas was removed. Oral Glucose Tolerance Test The oral glucose tolerance test was performed in overnight fasted normal rats [ 27 ].

Preliminary Phytochemical Tests The crude methanolic extract, hydroethanolic, ethyl acetate and petroleum ether fractions of Artemisia amygdalina were subjected to qualitative tests for identification of different constituents like alkaloids, flavonoids, terpenoids, phenolics, anthraquinones, glycosides, saponins and tannins by using standard qualitative methods described by Trease and Evans [ 28 ].

Results 3. Preliminary Phytochemical Analysis of Different Fractions of Artemisia amygdalina Preliminary screening of methanolic extracts revealed the presence of alkaloids, phenolics, and glycosides. Antihyperglycaemic Effect of Artemisia amygdalina The effect of extracts of Artemisia amygdalina and glibenclamide on serum glucose levels in normal, diabetic, and extract treated rats is presented in Table 1 a.

Table 1 a Effect of extracts of Artemisia amygdalina and glibenclamideon fasting blood glucose levels of rats. Open in a separate window. Table 2 Effect of extracts of Artemisia amygdalina and glibenclamide on various biochemical parameters in rats. Table 3 Effect of extracts of Artemisia amygdalina and glibenclamideon liver marker enzymes of streptozotocin induced diabetic rats.

Table 4 Effect of the extracts of Artemisia amygdalina and glibenclamideon feed intake and fluid intake of the rats.

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Effect of Extracts of Artemisia amygdalina and Glibenclamide on Body Weight in Rats The body weight of rats belonging to diabetic control group was drastically decreased upon the induction of diabetes. Table 5 Effect of extracts of Artemisia amygdalina and glibenclamideon body weight in streptozotocin induced diabetic rats. Figure 1. Table 6 a Effect of extracts of Artemisia amygdalina and glibenclamide on glucose tolerance of rats. Discussion Many Indian medicinal plants are reported to be useful in diabetes mellitus and many species of genus Artemisia have been reported to have antidiabetic activity [ 29 ].

Conflict of Interests The authors declare that they have no conflict of interests regarding the publication of this paper.

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Toxicology of oral antidiabetic medications. American Journal of Health-System Pharmacy. Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review. British Medical Journal. Saxena A, Vikram NK.

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Role of selected Indian plants in management of type 2 diabetes: a review. The Journal of Alternative and Complementary Medicine. Antidiabetic agents from medicinal plants.

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Current Medicinal Chemistry. Kachroo P, Nahvi IM.

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    Journal of Medicinal Plant Research. Willcox M. Artemisia species: from traditional medicines to modern antimalarials—and back again. Free radical scavenging potential of in vitro raised and greenhouse acclimatized plants of Artemisia amygdalina. Chinese Journal of Natural Medicines. Conservation of Artemisia amygdalina —acritically endangered endemic plant species of Kashmir Himalaya.

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